{"id":2527,"date":"2020-09-30T15:05:44","date_gmt":"2020-09-30T14:05:44","guid":{"rendered":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/?p=2527"},"modified":"2020-11-05T14:00:31","modified_gmt":"2020-11-05T13:00:31","slug":"centaur-i-fortitude-resultats-de-dos-nous-assaigs-clinics-sobre-lela","status":"publish","type":"post","link":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/centaur-i-fortitude-resultats-de-dos-nous-assaigs-clinics-sobre-lela\/","title":{"rendered":"Centaur i Fortitude, resultats de dos nous assaigs cl\u00ednics sobre l&#8217;ELA"},"content":{"rendered":"<p>Us informem de la publicaci\u00f3 de 2 articles relacionats amb sengles assaigs cl\u00ednics.<\/p>\n<p>El primer article fa refer\u00e8ncia a l&#8217;assaig CENTAUR, que es fa a una plataforma semblant al TRICALS que existeix a la costa Est dels Estats Units. L&#8217;assaig ha consistit en l&#8217;administraci\u00f3 de 2: 1 r\u00e0ti de fenilbutirat de sodi &#8211; taurursodiol (3 g de sodi fenilbutirat i 1 g de taurursodiol), a 177 subjectes, de 25 centres, durant 24 setmanes. S&#8217;ha observat un alentiment de la caiguda de l&#8217;escala funcional, per\u00f2 els autors conclouen que es necessiten m\u00e9s estudis i amb m\u00e9s durada.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1916945\">Vegeu l&#8217;estudi<\/a><\/li>\n<\/ul>\n<p>El segon article correspon a l&#8217;assaig FORTITUDE, basat en el Reldesemtiv, activador de la troponina de segona generaci\u00f3. El treball neix despr\u00e9s del frac\u00e0s de tirasemtiv per mala toler\u00e0ncia. Es fa l&#8217;assaig amb 4 bra\u00e7os: placebo \/ 150 mg \/ 300\/450 mg.<\/p>\n<p>No s&#8217;objectiven difer\u00e8ncies significatives en la variaci\u00f3 de la funci\u00f3 respirat\u00f2ria, que era l&#8217;objectiu, tot i que s\u00ed es veu una tend\u00e8ncia a que la caiguda de la funci\u00f3 respirat\u00f2ria sigui m\u00e9s lenta. Es plantegen estudis futurs.<\/p>\n<p><img loading=\"lazy\" class=\"alignnone size-full\" src=\"https:\/\/www.tandfonline.com\/na101\/home\/literatum\/publisher\/tandf\/journals\/content\/iafd20\/0\/iafd20.ahead-of-print\/21678421.2020.1822410\/20200924\/images\/medium\/iafd_a_1822410_f0001_c.jpg\" width=\"500\" height=\"295\" \/><\/p>\n<ul>\n<li><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/21678421.2020.1822410\">Vegeu l&#8217;estudi<\/a><\/li>\n<\/ul>\n<div class=\"sharedaddy sd-sharing-enabled\"><div class=\"robots-nocontent sd-block sd-social sd-social-icon sd-sharing\"><h3 class=\"sd-title\">Comparteix aix\u00f2:<\/h3><div class=\"sd-content\"><ul><li class=\"share-facebook\"><a rel=\"nofollow\" data-shared=\"sharing-facebook-2527\" class=\"share-facebook sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/centaur-i-fortitude-resultats-de-dos-nous-assaigs-clinics-sobre-lela\/?share=facebook\" target=\"_blank\" title=\"Comparteix al Facebook\"><span><\/span><span class=\"sharing-screen-reader-text\">Comparteix al Facebook (Opens in new window)<\/span><\/a><\/li><li class=\"share-twitter\"><a rel=\"nofollow\" data-shared=\"sharing-twitter-2527\" class=\"share-twitter sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/centaur-i-fortitude-resultats-de-dos-nous-assaigs-clinics-sobre-lela\/?share=twitter\" target=\"_blank\" title=\"Feu clic per compartir al Twitter\"><span><\/span><span class=\"sharing-screen-reader-text\">Feu clic per compartir al Twitter (Opens in new window)<\/span><\/a><\/li><li class=\"share-google-plus-1\"><a rel=\"nofollow\" data-shared=\"sharing-google-2527\" class=\"share-google-plus-1 sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/centaur-i-fortitude-resultats-de-dos-nous-assaigs-clinics-sobre-lela\/?share=google-plus-1\" target=\"_blank\" title=\"Feu clic per compartir a Google+\"><span><\/span><span class=\"sharing-screen-reader-text\">Feu clic per compartir a Google+ (Opens in new window)<\/span><\/a><\/li><li class=\"share-email\"><a rel=\"nofollow\" data-shared=\"\" class=\"share-email sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/centaur-i-fortitude-resultats-de-dos-nous-assaigs-clinics-sobre-lela\/?share=email\" target=\"_blank\" title=\"Feu clic per enviar un correu electr\u00f2nic a un amic\"><span><\/span><span class=\"sharing-screen-reader-text\">Feu clic per enviar un correu electr\u00f2nic a un amic (Opens in new window)<\/span><\/a><\/li><li class=\"share-print\"><a rel=\"nofollow\" data-shared=\"\" class=\"share-print sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/centaur-i-fortitude-resultats-de-dos-nous-assaigs-clinics-sobre-lela\/\" target=\"_blank\" title=\"Feu clic per imprimir\"><span><\/span><span class=\"sharing-screen-reader-text\">Feu clic per imprimir (Opens in new window)<\/span><\/a><\/li><li class=\"share-end\"><\/li><\/ul><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Us informem de la publicaci\u00f3 de 2 articles relacionats amb sengles assaigs cl\u00ednics. El primer article fa refer\u00e8ncia a l&#8217;assaig CENTAUR, que es fa a una plataforma semblant al TRICALS que existeix a la costa Est dels Estats Units. L&#8217;assaig &hellip; <a href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/centaur-i-fortitude-resultats-de-dos-nous-assaigs-clinics-sobre-lela\/\">Continua llegint <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n<div class=\"sharedaddy sd-sharing-enabled\"><div class=\"robots-nocontent sd-block sd-social sd-social-icon sd-sharing\"><h3 class=\"sd-title\">Comparteix aix\u00f2:<\/h3><div class=\"sd-content\"><ul><li class=\"share-facebook\"><a rel=\"nofollow\" data-shared=\"sharing-facebook-2527\" class=\"share-facebook sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/centaur-i-fortitude-resultats-de-dos-nous-assaigs-clinics-sobre-lela\/?share=facebook\" target=\"_blank\" title=\"Comparteix al Facebook\"><span><\/span><span class=\"sharing-screen-reader-text\">Comparteix al Facebook (Opens in new window)<\/span><\/a><\/li><li class=\"share-twitter\"><a rel=\"nofollow\" data-shared=\"sharing-twitter-2527\" class=\"share-twitter sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/centaur-i-fortitude-resultats-de-dos-nous-assaigs-clinics-sobre-lela\/?share=twitter\" target=\"_blank\" title=\"Feu clic per compartir al Twitter\"><span><\/span><span class=\"sharing-screen-reader-text\">Feu clic per compartir al Twitter (Opens in new window)<\/span><\/a><\/li><li class=\"share-google-plus-1\"><a rel=\"nofollow\" data-shared=\"sharing-google-2527\" class=\"share-google-plus-1 sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/centaur-i-fortitude-resultats-de-dos-nous-assaigs-clinics-sobre-lela\/?share=google-plus-1\" target=\"_blank\" title=\"Feu clic per compartir a Google+\"><span><\/span><span class=\"sharing-screen-reader-text\">Feu clic per compartir a Google+ (Opens in new window)<\/span><\/a><\/li><li class=\"share-email\"><a rel=\"nofollow\" data-shared=\"\" class=\"share-email sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/centaur-i-fortitude-resultats-de-dos-nous-assaigs-clinics-sobre-lela\/?share=email\" target=\"_blank\" title=\"Feu clic per enviar un correu electr\u00f2nic a un amic\"><span><\/span><span class=\"sharing-screen-reader-text\">Feu clic per enviar un correu electr\u00f2nic a un amic (Opens in new window)<\/span><\/a><\/li><li class=\"share-print\"><a rel=\"nofollow\" data-shared=\"\" class=\"share-print sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/centaur-i-fortitude-resultats-de-dos-nous-assaigs-clinics-sobre-lela\/\" target=\"_blank\" title=\"Feu clic per imprimir\"><span><\/span><span class=\"sharing-screen-reader-text\">Feu clic per imprimir (Opens in new window)<\/span><\/a><\/li><li class=\"share-end\"><\/li><\/ul><\/div><\/div><\/div>","protected":false},"author":10,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[102,83],"tags":[986,990,988,994,992],"_links":{"self":[{"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/posts\/2527"}],"collection":[{"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/comments?post=2527"}],"version-history":[{"count":8,"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/posts\/2527\/revisions"}],"predecessor-version":[{"id":2572,"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/posts\/2527\/revisions\/2572"}],"wp:attachment":[{"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/media?parent=2527"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/categories?post=2527"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/tags?post=2527"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}