{"id":1036,"date":"2016-10-17T10:38:13","date_gmt":"2016-10-17T09:38:13","guid":{"rendered":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/?p=1036"},"modified":"2019-01-30T14:07:49","modified_gmt":"2019-01-30T13:07:49","slug":"la-compleja-patogenesis-de-la-ela","status":"publish","type":"post","link":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/la-compleja-patogenesis-de-la-ela\/","title":{"rendered":"La compleja patog\u00e9nesis de la ELA"},"content":{"rendered":"<p style=\"text-align: justify;\">La esclerosis lateral amiotr\u00f3fica (ELA) es una enfermedad neurogenerativa con una <a href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-content\/uploads\/sites\/2\/2016\/10\/patogenesis-en-ela.pdf\">patog\u00e9nesis compleja<\/a>\u00a0que implica m\u00faltiples factores: neuroinflamaci\u00f3n, autofagia, estr\u00e9s oxidativo, alteraciones mitocondriales y exitotoxicidad, entre otros.<\/p>\n<p style=\"text-align: justify;\"><a href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-content\/uploads\/sites\/2\/2016\/10\/patogenesis-en-ela.pdf\"><img loading=\"lazy\" class=\"aligncenter wp-image-1037\" src=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-content\/uploads\/sites\/2\/2016\/10\/patogenesis_ELA-300x152.jpg\" alt=\"patogenesis_ela\" width=\"600\" height=\"304\" srcset=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-content\/uploads\/sites\/2\/2016\/10\/patogenesis_ELA-300x152.jpg 300w, http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-content\/uploads\/sites\/2\/2016\/10\/patogenesis_ELA-768x389.jpg 768w, http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-content\/uploads\/sites\/2\/2016\/10\/patogenesis_ELA.jpg 800w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/a><\/p>\n<p style=\"text-align: justify;\">Un 10% de formas de la enfermedad son familiares, en las cuales se han identificado m\u00e1s de 20 genes implicados. De estos genes, solo un 10% se asocian a formas familiares.<\/p>\n<p style=\"text-align: justify;\">La epigen\u00e9tica va a permitir relacionar los factores ambientales con las alteraciones gen\u00e9ticas, muchas de las cuales favorecen la autofagia, neuroinflamaci\u00f3n y agregaci\u00f3n proteica. Se desconocen los factores desencadenantes que ponen en marcha todo el proceso, ni los mecanismos de propagaci\u00f3n de la enfermedad, pero est\u00e1 claro que el <a href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-content\/uploads\/sites\/2\/2016\/10\/exoma-y-ela.pdf\">estudio del exoma<\/a>\u00a0y genoma nos ayudar\u00e1 a tener un mejor conocimiento de esta compleja enfermedad.<\/p>\n<p style=\"text-align: justify;\">Por este hecho, el Hospital Universitario de Bellvitge guarda el DNA de los pacientes y participa en el <a href=\"https:\/\/www.projectmine.com\/es\/\">proyecto MINE<\/a>, en el que vamos a contribuir enviando 60 muestras de ADN para su estudio. A su vez, adquiere gran importancia la obtenci\u00f3n de ADN de sujetos sanos para estudio de poblaci\u00f3n control.<\/p>\n<p style=\"text-align: justify;\">Unidad Funcional de Motoneurona del HUB<\/p>\n<div class=\"sharedaddy sd-sharing-enabled\"><div class=\"robots-nocontent sd-block sd-social sd-social-icon sd-sharing\"><h3 class=\"sd-title\">Comparteix aix\u00f2:<\/h3><div class=\"sd-content\"><ul><li class=\"share-facebook\"><a rel=\"nofollow\" data-shared=\"sharing-facebook-1036\" class=\"share-facebook sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/la-compleja-patogenesis-de-la-ela\/?share=facebook\" target=\"_blank\" title=\"Comparteix al Facebook\"><span><\/span><span class=\"sharing-screen-reader-text\">Comparteix al Facebook (Opens in new window)<\/span><\/a><\/li><li class=\"share-twitter\"><a rel=\"nofollow\" data-shared=\"sharing-twitter-1036\" class=\"share-twitter sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/la-compleja-patogenesis-de-la-ela\/?share=twitter\" target=\"_blank\" title=\"Feu clic per compartir al Twitter\"><span><\/span><span class=\"sharing-screen-reader-text\">Feu clic per compartir al Twitter (Opens in new window)<\/span><\/a><\/li><li class=\"share-google-plus-1\"><a rel=\"nofollow\" data-shared=\"sharing-google-1036\" class=\"share-google-plus-1 sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/la-compleja-patogenesis-de-la-ela\/?share=google-plus-1\" target=\"_blank\" title=\"Feu clic per compartir a Google+\"><span><\/span><span class=\"sharing-screen-reader-text\">Feu clic per compartir a Google+ (Opens in new window)<\/span><\/a><\/li><li class=\"share-email\"><a rel=\"nofollow\" data-shared=\"\" class=\"share-email sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/la-compleja-patogenesis-de-la-ela\/?share=email\" target=\"_blank\" title=\"Feu clic per enviar un correu electr\u00f2nic a un amic\"><span><\/span><span class=\"sharing-screen-reader-text\">Feu clic per enviar un correu electr\u00f2nic a un amic (Opens in new window)<\/span><\/a><\/li><li class=\"share-print\"><a rel=\"nofollow\" data-shared=\"\" class=\"share-print sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/la-compleja-patogenesis-de-la-ela\/\" target=\"_blank\" title=\"Feu clic per imprimir\"><span><\/span><span class=\"sharing-screen-reader-text\">Feu clic per imprimir (Opens in new window)<\/span><\/a><\/li><li class=\"share-end\"><\/li><\/ul><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>La esclerosis lateral amiotr\u00f3fica (ELA) es una enfermedad neurogenerativa con una patog\u00e9nesis compleja\u00a0que implica m\u00faltiples factores: neuroinflamaci\u00f3n, autofagia, estr\u00e9s oxidativo, alteraciones mitocondriales y exitotoxicidad, entre otros. Un 10% de formas de la enfermedad son familiares, en las cuales se han &hellip; <a href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/la-compleja-patogenesis-de-la-ela\/\">Continua llegint <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n<div class=\"sharedaddy sd-sharing-enabled\"><div class=\"robots-nocontent sd-block sd-social sd-social-icon sd-sharing\"><h3 class=\"sd-title\">Comparteix aix\u00f2:<\/h3><div class=\"sd-content\"><ul><li class=\"share-facebook\"><a rel=\"nofollow\" data-shared=\"sharing-facebook-1036\" class=\"share-facebook sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/la-compleja-patogenesis-de-la-ela\/?share=facebook\" target=\"_blank\" title=\"Comparteix al Facebook\"><span><\/span><span class=\"sharing-screen-reader-text\">Comparteix al Facebook (Opens in new window)<\/span><\/a><\/li><li class=\"share-twitter\"><a rel=\"nofollow\" data-shared=\"sharing-twitter-1036\" class=\"share-twitter sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/la-compleja-patogenesis-de-la-ela\/?share=twitter\" target=\"_blank\" title=\"Feu clic per compartir al Twitter\"><span><\/span><span class=\"sharing-screen-reader-text\">Feu clic per compartir al Twitter (Opens in new window)<\/span><\/a><\/li><li class=\"share-google-plus-1\"><a rel=\"nofollow\" data-shared=\"sharing-google-1036\" class=\"share-google-plus-1 sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/la-compleja-patogenesis-de-la-ela\/?share=google-plus-1\" target=\"_blank\" title=\"Feu clic per compartir a Google+\"><span><\/span><span class=\"sharing-screen-reader-text\">Feu clic per compartir a Google+ (Opens in new window)<\/span><\/a><\/li><li class=\"share-email\"><a rel=\"nofollow\" data-shared=\"\" class=\"share-email sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/la-compleja-patogenesis-de-la-ela\/?share=email\" target=\"_blank\" title=\"Feu clic per enviar un correu electr\u00f2nic a un amic\"><span><\/span><span class=\"sharing-screen-reader-text\">Feu clic per enviar un correu electr\u00f2nic a un amic (Opens in new window)<\/span><\/a><\/li><li class=\"share-print\"><a rel=\"nofollow\" data-shared=\"\" class=\"share-print sd-button share-icon no-text\" href=\"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/la-compleja-patogenesis-de-la-ela\/\" target=\"_blank\" title=\"Feu clic per imprimir\"><span><\/span><span class=\"sharing-screen-reader-text\">Feu clic per imprimir (Opens in new window)<\/span><\/a><\/li><li class=\"share-end\"><\/li><\/ul><\/div><\/div><\/div>","protected":false},"author":10,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[6,1],"tags":[161,162,159,160],"_links":{"self":[{"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/posts\/1036"}],"collection":[{"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/comments?post=1036"}],"version-history":[{"count":8,"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/posts\/1036\/revisions"}],"predecessor-version":[{"id":1052,"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/posts\/1036\/revisions\/1052"}],"wp:attachment":[{"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/media?parent=1036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/categories?post=1036"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/blogs.bellvitgehospital.cat\/aulaela\/wp-json\/wp\/v2\/tags?post=1036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}